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Researchers from the University of California, San Francisco used a genome-scale CRISPR interference (CRISPRi) functional genomics system to methodically identify genetic interactions with a mutant type of KRAS called KRASG12C, and discovered combination treatments that target genes associated with its activity.

Genetic interactions of mutant KRAS revealed with CRISPR

Researchers from the University of California, San Francisco used a genome-scale CRISPR interference (CRISPRi) functional genomics system to methodically identify genetic interactions with a mutant type of KRAS called KRASG12C, and discovered combination treatments that target genes associated with its activity.

Reversible editing by new CRISPR technology reduces off-target effects

McGovern Institute Investigator and Broad Institute of MIT and also Harvard core member Feng Zhang and his group have now established one such approach, called RESCUE (RNA Editing for Specific C to U Exchange). RESCUE targets one of the four main "bases" of RNA, cytosine. Utilizing a programmable enzyme, Zhang's team converted pathogenic cytosine into uridine, which in turn altered the guidelines RNA offered, say, protein synthesis.
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